Title: Breathing new life into air pollution research: recycling medical waste tissues for inhalation toxicology
Speaker: Dr. Kelly BéruBé, School of Biosciences, Cardiff University, Wales, UK
Date: Friday March 20th, 2015
Where: Access webinar via https://bluejeans.com/243730215
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With the advent of bio-banks to store human lung cells from human patient donations and from the procurement of medical waste tissues post-surgery, it is now possible to integrate (both spatially and temporally) cells into anatomically-correct and physiologically-functional tissues. Modern inhalation toxicology relies on human data on exposure and adverse effects, to determine the most appropriate risk assessments and mitigations for beneficial respiratory health. A point in case is the recapitulation of airway tissue, such as the bronchial epithelium, to investigate the impact of air pollution (i.e. particles and gases) on human respiratory health. The bronchi are the first point of contact for inhaled substances that by-pass defences in the upper respiratory tract. Animal models have been used to resolve such inhalation toxicology hazards. However, the access to medical waste tissues has enabled the Lung & Particle Research Group at Cardiff University to tissue-engineer the Micro-Lung™ and Metabo-Lung™ cell culture models, as alternatives to using animals for inhalation experiments. The former model favours investigations focused on lung injury and repair mechanisms, and the latter model provides the element of metabolism, through the co-culturing of lung (bronchial) and liver (hepatocyte) cells. These innovations represent examples of the animal-free alternatives advocated by the 21st Century toxicology paradigm (i.e. NRC, USA) whereby human-derived cell/tissue data will lead to more-accurate and more-reliable public health risk assessments and therapeutic mitigations (e.g. exposure to ambient air pollutants) for lung disease.
(Read more about Dr Kelly BéruBé: http://www.cardiff.ac.uk/biosi/contactsandpeople/stafflist/a-d/berube-kelly-dr-biography_new.html)