An upcoming seminar talk:
Airway Hypersensitivity Induced by Exposure to Organic Aerosol
by Dr. Arthur Chan
Assistant Professor, Department of Chemical Engineering and Applied Chemistry, University of Toronto
Host: Dr. Allan Bertram, Chemistry & Dr. Chris Carlsten, SPPH
Date: Tuesday, March 8th, 3:30-4:30pm
Location: Room D215, Chemistry Building, 2036 Main Mall
Epidemiologic studies have shown that particulate matter (PM) is associated with the incidence, morbidity and mortality of cardiopulmonary diseases. PM is mostly comprised of Secondary Organic Aerosols (SOA), formed through secondary reactions in the atmosphere. Here we study the in vivo pulmonary effects on mice exposed to lab-generated SOA. Healthy 8-10 weeks old female mice were exposed for 1 hr/day for 3 consecutive days to SOA from naphthalene oxidation (N-SOA), maintained at levels to simulate street-level concentrations during exposures. Pulmonary function and methacholine (MCh)- responsiveness were assessed 24 hours after the final exposure. After exposure to N-SOA, significant increases in total respiratory resistance were observed when compared to control filtered-air mice, and in a dose-dependent manner. However, the total and differential leukocyte counts in the broncho-alveolar lavage fluid were similar in all experimental groups, suggesting that increase in airway responsiveness was not associated with airway inflammation and may be triggered by non-inflammatory pathways.
Dr. Arthur Chan has been an Assistant Professor in Chemical Engineering and Applied Chemistry at University of Toronto since 2013. His research focuses on the sources, transformations and impacts of organic aerosol in the atmosphere. Arthur Chan received his Ph.D. in 2010 from Caltech studying the oxidation chemistry of organic compounds leading to SOA formation, and completed his postdoctoral work developing analytical techniques for atmospheric organic mixtures.
(Last updated: March 2nd, 2016)